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Santaquin (/ˈsæntəkwɪn/ SAN-tə-kwin) is a city in Utah and Juab counties in the U.S. state of Utah. It is allowance of the Provo–Orem metropolitan area. The population was 9,128 at the 2010 census and an estimated 12,274 in 2018.

Santaquin, one of the early settlements along the Salt Lake Road, was originally decided in late 1851. It was originally named Summit City because of its location near the summit of the divide between Utah Valley and Juab Valley. Summit City was approved by pioneers who were helping settle nearby Payson to the north. In 1856 it was renamed “Santaquin” for the son of Guffich, a local original chieftain friendly to the settlers. Santaquin incorporated as a town in the 1890s and untouched to a city in action January 4, 1932.

Santaquin lies southeast of Utah Lake in southern Utah County, with a little portion extending south into Juab County. It is bordered to the northwest by Genola and to the north by unincorporated Spring Lake. Interstate 15 passes through the city, with entrance from Exits 242 and 244. I-15 leads north 21 miles (34 km) to Provo and south 19 miles (31 km) to Nephi. U.S. Route 6 passes through Santaquin as Main Street and leads west 24 miles (39 km) to Silver City. Utah State Route 198 leads north from I-15 5 miles (8 km) to Payson.